Saturday, July 7, 2012

VePesid


Pronunciation: EH-toe-POE-side
Generic Name: Etoposide
Brand Name: VePesid

VePesid may decrease your body's ability to fight infections (due to bone marrow suppression). Immediately notify your doctor if you develop symptoms of an infection (persistent sore throat, fever), easy bruising or bleeding, or unusual fatigue. Your doctor will closely monitor you while you are using VePesid.





VePesid is used for:

Treating patients with lung cancer and recurrent testicular tumors. It is used in combination with other cancer medications.


VePesid is an antineoplastic. It works by stopping the tumor cells from dividing (mitosis), which prevents the spread of certain types of cancer.


Do NOT use VePesid if:


  • you are allergic to any ingredient in VePesid

Contact your doctor or health care provider right away if any of these apply to you.



Before using VePesid:


Some medical conditions may interact with VePesid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have kidney disease, bone marrow depression, an infection, or a history of blood conditions

Some MEDICINES MAY INTERACT with VePesid. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Anticoagulants (eg, warfarin) because their actions and side effects may be increased by VePesid

  • Cyclosporine because the actions and side effects of VePesid may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if VePesid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use VePesid:


Use VePesid as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.


  • VePesid may be taken with or without food.

  • If you miss a dose of VePesid, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use VePesid.



Important safety information:


  • VePesid may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to VePesid. Using VePesid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

  • If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.

  • VePesid may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

  • VePesid may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.

  • Check with your doctor before having vaccinations while you are using VePesid.

  • LAB TESTS, including complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

  • Use VePesid with caution in the ELDERLY because they may be more sensitive to its effects.

  • VePesid is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: VePesid has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using VePesid during pregnancy. It is unknown if VePesid is excreted in breast milk. Do not breast-feed while taking VePesid.


Possible side effects of VePesid:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Appetite loss; bruising; diarrhea; hair loss; increased sweating; nausea; voice changes; vomiting.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chills; cough; decreased ability to fight infection; dizziness; fever; loss of consciousness; seizure; sore throat; sores on the mouth or lips; temporary blindness; tingling of the fingers or toes; unusual bruising or bleeding; unusual tiredness.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: VePesid side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of VePesid:

Store VePesid in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep VePesid out of the reach of children and away from pets.


General information:


  • If you have any questions about VePesid, please talk with your doctor, pharmacist, or other health care provider.

  • VePesid is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about VePesid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More VePesid resources


  • VePesid Side Effects (in more detail)
  • VePesid Use in Pregnancy & Breastfeeding
  • Drug Images
  • VePesid Drug Interactions
  • VePesid Support Group
  • 0 Reviews for VePesid - Add your own review/rating


  • VePesid Prescribing Information (FDA)

  • VePesid Concise Consumer Information (Cerner Multum)

  • Etoposide Prescribing Information (FDA)

  • Etoposide Monograph (AHFS DI)

  • Etoposide Professional Patient Advice (Wolters Kluwer)

  • etoposide Advanced Consumer (Micromedex) - Includes Dosage Information

  • Toposar Prescribing Information (FDA)

  • Vepesid Advanced Consumer (Micromedex) - Includes Dosage Information



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Thursday, July 5, 2012

CortAlo With Aloe


Generic Name: hydrocortisone (Topical application route)

hye-droe-KOR-ti-sone

Commonly used brand name(s)

In the U.S.


  • Ala-Cort

  • Ala-Scalp HP

  • Anusol HC

  • Aquanil HC

  • Beta HC

  • Caldecort

  • Cetacort

  • Corta-Cap

  • Cortagel Extra Strength

  • Cortaid

  • CortAlo With Aloe

  • Corticaine

  • Corticool Maximum Strength

  • Cortizone-10

  • Cortizone-5

  • Cotacort

  • Delacort

  • Dermarest

  • Dermtex-HC

  • Foille Cort

  • Gly-Cort

  • Hydrozone Plus

  • Hytone

  • Instacort-10

  • Ivy Soothe

  • IvyStat

  • Keratol HC

  • Kericort 10

  • Lacticare-HC

  • Locoid

  • Locoid Lipocream

  • Medi-Cortisone Maximum Strength

  • Microcort

  • Mycin Scalp

  • Neutrogena T/Scalp

  • NuCort

  • Nupercainal HC

  • Nutracort

  • Pandel

  • Pediaderm HC Kit

  • Preparation H Hydrocortisone

  • Proctocream-HC

  • Recort Plus

  • Sarnol-HC Maximum Strength

  • Scalacort

  • Scalpcort

  • Summer's Eve Specialcare

  • Texacort

  • Therasoft Anti-Itch & Dermatitis

  • U-Cort

  • Westcort

In Canada


  • Barriere-Hc

  • Cortate

  • Cort-Eze

  • Cortoderm Mild Ointment

  • Cortoderm Regular Ointment

  • Emo-Cort

  • Emo-Cort Scalp Solution

  • Hydrocortisone Cream

  • Novo-Hydrocort

  • Novo-Hydrocort Cream

  • Prevex Hc

  • Sarna Hc

Available Dosage Forms:


  • Solution

  • Cream

  • Spray

  • Lotion

  • Ointment

  • Pad

  • Liquid

  • Gel/Jelly

  • Kit

  • Foam

  • Stick

  • Paste

Therapeutic Class: Corticosteroid, Weak


Pharmacologic Class: Adrenal Glucocorticoid


Uses For CortAlo With Aloe


Hydrocortisone topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).


This medicine is available both over-the-counter (OTC) and with your doctor's prescription.


Before Using CortAlo With Aloe


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of hydrocortisone topical in the pediatric population. However, because of this medicine's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using this medicine, follow your doctor's instructions very carefully.


Geriatric


No information is available on the relationship of age to the effects of hydrocortisone topical in geriatric patients.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.


Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Cushing's syndrome (adrenal gland disorder) or

  • Diabetes or

  • Hyperglycemia (high blood sugar) or

  • Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

  • Infection of the skin at or near the place of application or

  • Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

Proper Use of hydrocortisone

This section provides information on the proper use of a number of products that contain hydrocortisone. It may not be specific to CortAlo With Aloe. Please read with care.


It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.


This medicine is for use on the skin only. Do not get it in your eyes. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.


This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.


To use:


  • Wash your hands with soap and water before and after using this medicine.

  • Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

  • With the lotion, shake it well before using.

  • Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

  • If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

  • If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For redness, itching, and swelling of the skin:
    • For topical dosage form (cream):
      • Adults—Apply to the affected area of the skin two or three times per day.

      • Children—Apply to the affected area of the skin two or three times per day.


    • For topical dosage form (lotion):
      • Adults—Apply to the affected area of the skin two to four times per day.

      • Children—Apply to the affected area of the skin two to four times per day.


    • For topical dosage form (ointment):
      • Adults—Apply to the affected area of the skin three or four times per day.

      • Children—Apply to the affected area of the skin three or four times per day.


    • For topical dosage form (solution):
      • Adults—Apply to the affected area of the skin three or four times per day.

      • Children—Apply to the affected area of the skin three or four times per day.



Missed Dose


If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using CortAlo With Aloe


It is very important that your doctor check your or your child's progress at regular visits for any unwanted effects that may be caused by this medicine.


If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.


Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.


Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.


Do not use cosmetics or other skin care products on the treated areas.


CortAlo With Aloe Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin

  • irritation

  • itching, scaling, severe redness, soreness, or swelling of the skin

  • redness and scaling around the mouth

  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)

  • thinning, weakness, or wasting away of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Incidence not known
  • Acne or pimples

  • burning and itching of the skin with pinhead-sized red blisters

  • burning, itching, and pain in hairy areas, or pus at the root of the hair

  • increased hair growth on the forehead, back, arms, and legs

  • lightening of normal skin color

  • lightening of treated areas of dark skin

  • reddish purple lines on the arms, face, legs, trunk, or groin

  • softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: CortAlo With Aloe side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More CortAlo With Aloe resources


  • CortAlo With Aloe Side Effects (in more detail)
  • CortAlo With Aloe Use in Pregnancy & Breastfeeding
  • CortAlo With Aloe Drug Interactions
  • 0 Reviews for CortAlo With Aloe - Add your own review/rating


  • Anucort-HC cream, ointment, suppository Concise Consumer Information (Cerner Multum)

  • Anusol-HC Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Carmol HC Prescribing Information (FDA)

  • Carmol HC Concise Consumer Information (Cerner Multum)

  • Carmol HC MedFacts Consumer Leaflet (Wolters Kluwer)

  • Cortalo with Aloe Concise Consumer Information (Cerner Multum)

  • Cortizone-10 Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Hydrocortisone Acetate Monograph (AHFS DI)

  • Hydrocortisone with Aloe Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Hytone Prescribing Information (FDA)

  • Instacort Gel MedFacts Consumer Leaflet (Wolters Kluwer)

  • Locoid Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Locoid Lipocream Prescribing Information (FDA)

  • Locoid Lotion Prescribing Information (FDA)

  • Nutracort Concise Consumer Information (Cerner Multum)

  • Nutracort Lotion MedFacts Consumer Leaflet (Wolters Kluwer)

  • Pandel Prescribing Information (FDA)

  • Pediaderm HC Lotion MedFacts Consumer Leaflet (Wolters Kluwer)

  • ProctoCream-HC Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Proctocort Prescribing Information (FDA)

  • Texacort Prescribing Information (FDA)

  • U-cort Prescribing Information (FDA)

  • Westcort Prescribing Information (FDA)



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Morphgesic 100mg Tablets





1. Name Of The Medicinal Product



Rhotard Morphine SR 100 mg Tablets



Morphgesic SR 100 mg Tablets


2. Qualitative And Quantitative Composition



Rhotard Morphine SR 100 mg Tablets/ Morphgesic SR 100mg Tablets contain 100mg Morphine Sulphate.



Each 100mg tablet is a grey coloured biconvex round film coated tablet.



3. Pharmaceutical Form



Controlled release tablets



4. Clinical Particulars



4.1 Therapeutic Indications



For the prolonged relief of severe pain.



4.2 Posology And Method Of Administration



Route of administration: Oral



Rhotard Morphine SR / Morphgesic SR tablets should be swallowed whole and not chewed.



Adults:



The dosage is dependent upon the severity of the pain and the patient's previous history of analgesic requirements. The tablets should normally be administered twice daily at 12 hourly intervals. One or two 10 mg tablets (10mg) twice daily is the recommended starting dosage for a patient presenting with severe pain. With increasing severity of pain it is recommended that the dosage of morphine be increased to achieve the desired relief. The dosage may be varied by choosing combinations of available strengths (10, 30, 60, and 100 mg) or by using higher strength tablets alone.



It is recommended that a patient transferred from another oral morphine preparation, having similar bioavailability to oral morphine liquid, should receive the same total morphine dose in one 24-hour period. This total dose should be divided between the morning and evening administration. Dosage titration and clinical assessment may be appropriate.



Where a patient had previously received parenteral morphine prior to being transferred to Rhotard Morphine SR/ Morphgesic SR tablets, a higher dosage of morphine may be required. Individual dosage adjustment will be necessary to compensate for any reduction in analgesic effect associated with oral administration.



When Rhotard Morphine SR/ Morphgesic SR is to be given for the relief of post-operative pain, it is not advisable to administer it during the first 24 hours. Following this initial period, the dosage should be at the physician's discretion.



Some patients may require supplemental parenteral morphine which is perfectly acceptable. Careful attention should be paid to the total morphine dosage however, and the prolonged effects of morphine in the Rhotard Morphine SR/ Morphgesic SR formulation should also be borne in mind.



Rhotard Morphine SR/ Morphgesic SR tablets should be used with caution post-operatively (as with all morphine preparations) but especially in cases of 'acute abdomen' and following abdominal surgery.



Gastric motility should have returned and be maintained.



Children:



Rhotard Morphine SR/ Morphgesic SR tablets are not recommended for paediatric use.



4.3 Contraindications



Respiratory depression, paralytic ileus, delayed gastric emptying, obstructive airways disease, known morphine sensitivity or acute hepatic disease. It is also contra-indicated in the presence of hypersensitivity to any of the constituents, acute alcoholism, head injuries and conditions in which intracranial pressure is raised. Neither should it be given during an attack of bronchial asthma nor heart failure secondary to chronic lung disease.



Not recommended for pre-operative use or for the first 24 hours post-operatively.



Not recommended during pregnancy and lactation.



Concurrent administration of monoamine oxidase inhibitors (MAOIs) or within two weeks of discontinuation of their use.



4.4 Special Warnings And Precautions For Use



Rhotard Morphine SR/ Morphgesic SR tablets should be given with caution or in reduced doses to patients with hypothyroidism, adrenocortical insufficiency, impaired kidney or liver function, prostatic hypertrophy or shock. It should be used with caution in patients with either obstructive bowel disorders or myasthenia gravis.



Caution in patients with convulsive disorders, hypotension with hypovolaemia, the elderly, opioid dependent patients, diseases of the biliary tract, pancreatitis and inflammatory bowel disorders.



Should not be used where there is a possibility of paralytic ileus occurring. Should paralytic ileus be suspected to occur during use, treatment should be discontinued immediately.



As with all morphine preparations, patients who are to undergo cordotomy or other pain relieving surgical procedures should not receive Rhotard Morphine SR/ Morphgesic SR tablets for 24 hours prior to surgery. If further treatment is then indicated, the dosage should be adjusted to the new post-operative requirement.



It is not possible to ensure bio-equivalence between different brands of controlled release morphine products. Therefore, it should be emphasised that patients, once titrated to an effective dose should not be changed from Rhotard Morphine SR/ Morphgesic SR tablets to other slow, sustained or controlled release morphine or other potent narcotic analgesic preparations without retitration and clinical assessment.



4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction



Rhotard Morphine SR/ Morphgesic SR tablets should not be concurrently administered with monoamine oxidase inhibitors (MAOI's) or used within two weeks of discontinuation of MAOI use. The depressant effects of morphine are enhanced by depressants of the central nervous system such as alcohol, anaesthetics, hypnotics and sedatives, tricyclic antidepressants and phenothiazines. The action of morphine may in turn affect the activities of other compounds, for example its gastro-intestinal effects may delay absorption as with mexilitine or may be counteractive as with metoclopramide.



Cimetidine inhibits the metabolism of morphine.



Morphine potentiates the effects of tranquillisers, muscle relaxants and anti-hypertensives.



Mixed agonist/antagonist opioid analgesics (e.g. Buprenorphine, nalbuphine, pentazocine) should not be administered to a patient who has received a course of therapy with a pure opioid agonist analgesic.



4.6 Pregnancy And Lactation



Rhotard Morphine SR/ Morphgesic SR tablets are contraindicated during pregnancy and lactation.



4.7 Effects On Ability To Drive And Use Machines



Patients taking Rhotard Morphine SR/ Morphgesic SR tablets should not operate machines.



4.8 Undesirable Effects



The commonest side-effects of morphine when administered at normal doses are nausea, vomiting, constipation, drowsiness and confusion. Micturition may be difficult and there may be ureteric or biliary spasm. There is also an antidiuretic effect. Dry mouth, sweating, facial flushing, vertigo, bradycardia, palpitations, orthostatic hypothermia, restlessness, changes of mood and miosis also occur. These effects occur more commonly in ambulant patients than in those at rest in bed. Raised intracranial pressure occurs in some patients. Larger doses of morphine produce respiratory depression and hypotension with circulatory failure and deepening coma. Death may occur from respiratory failure. Toxic doses vary considerably with the individual. Tolerance and dependence may occur.



Paralytic ileus may be associated with opioid usage. Other effects include bronchospasm, headache, disorientation, hallucinations, rash, myoclonus, decreased libido and colic.



Morphine has histamine releasing effects which may be responsible in part for reactions such as urticaria and pruritus.



4.9 Overdose



In acute poisoning by Rhotard Morphine SR/ Morphgesic SR tablets, the stomach should be emptied by aspiration and lavage. A laxative may be given to aid peristalsis. Signs of morphine toxicity and overdose are likely to consist of pin-point pupils, respiratory depression and hypotension. Circulatory failure and deepening coma may occur in more severe cases.



Treatment of respiratory failure and shock may require intensive supportive therapy. In addition to this the specific antagonist naloxone hydrochloride should be administered at a dose of 0.4 to 2 mg iv. This dose should be repeated at intervals of 2 to 3 minutes if required, up to a total dose of 10mg.



The physician should be aware that Rhotard Morphine SR/ Morphgesic SR tablets remaining in the intestine will continue to release morphine sulphate for a period of hours.



Rhabdomyolysis progressing to renal failure has been reported in opioid overdosage.



5. Pharmacological Properties



5.1 Pharmacodynamic Properties



Morphine is an opioid analgesic. It acts mainly on the central nervous system and on smooth muscle. Although morphine is predominantly a central nervous system depressant it has some central stimulant actions which results in nausea and vomiting and miosis. Morphine generally increases smooth muscle tone, especially the sphincters of the gastro-intestinal tract.



Morphine and related analgesics may produce both physical and psychological dependence and should therefore be used with discrimination. Tolerance may also develop.



Morphine is an analgesic used for the symptomatic relief of moderate to severe pain, especially that associated with neoplastic disease, myocardial infarction and surgery. When pain is likely to be short of duration, a short-acting analgesic is usually preferred in addition to relieving pain, morphine also alleviates the anxiety associated with severe pain. It is useful as a hypnotic where sleeplessness is due to pain and may also relieve the pain of biliary or renal colic, although an antispasmodic may also be required since morphine may increase smooth muscle tone.



Morphine reduces intestinal motility and is used in the symptomatic treatment of diarrhoea. It also relieves the dyspnoea of left ventricular failure and of pulmonary oedema. It is effective for the suppression of cough, but codeine is usually preferred as there is less risk of dependence. Morphine has been used



pre-operatively as an adjunct to anaesthesia for pain relief and to allay anxiety. It has also been used in high doses as a general anaesthetic in specialised procedures. Morphine is usually administered as the sulphate, although the hydrochloride and the tartrate are used in similar doses; the acetate has also been used. Routes of administration include the oral, subcutaneous, intramuscular, intravenous, intraspinal and rectal routes. Parenteral doses may be intermittent injections or continuous or intermittent infusions adjusted according to individual analgesic requirements.



5.2 Pharmacokinetic Properties



Morphine has a plasma half life of about 2 to 3 hours and if given IV must be administered frequently. Rhotard Morphine SR/ Morphgesic SR, being a sustained release preparation of morphine, has the advantage that it is only administered twice daily.



A summary of the morphine pharmacokinetic parameters is given below:



(a) Half life; plasma half life; about 2-3 hours



(b) Volume of distribution; about 3-5 litres/KG



(c) Clearance; plasma clearance; about 15 to 20 ml/min/kg



(d) Protein binding; in plasma 20-35%



Pharmacokinetic parameters pertinent to Rhotard Morphine SR/ Morphgesic SR tablets are summarised in the following table:
















Parameters




Rhotard Morphine SR/ Morphgesic SR Tablets



Fasting (A)




Rhotard Morphine SR/ Morphgesic SR Tablets



Food (B)




AUC (0-t)



(ng.h/ml)




46.02 ± 18.85




59.88 ± 20.52




Cmax



(ng/ml)




9.2 ± 3.6




13.6 ± 4.6




T max



hours




2.5 ± 1.7




3.9 ± 1.6



5.3 Preclinical Safety Data



No preclinical safety data are available which are additional to the experience gained in man with morphine over many years.



6. Pharmaceutical Particulars



6.1 List Of Excipients



Hydroxyethylcellulose, Hypromellose (E464), Povidone, Talc, Magnesium Stearate, Macrogol and Industrial Methylated Spirits 99% BP.



Rhotard Morphine SR/ Morphgesic SR 100 mg tablets contain the colourants listed below:



Titanium Dioxide (E171)



Iron Oxide Black (172)



6.2 Incompatibilities



None.



6.3 Shelf Life



36 Months



6.4 Special Precautions For Storage



Do not store above 25°C. Store in the original package.



6.5 Nature And Contents Of Container



Each pack contains either 10 or 60 tablets in PVC blister packs with aluminium foil lidding.



6.6 Special Precautions For Disposal And Other Handling



None.



7. Marketing Authorisation Holder



Waymade plc



Trading as: Sovereign Medical



Sovereign House



Miles Gray Road



Basildon



Essex.



SS14 3FR



United Kingdom



And trading as Amdipharm



Regency House



Miles Gray Road



Basildon



Essex



SS14 3AF



United Kingdom



8. Marketing Authorisation Number(S)



PL 06464/1654



9. Date Of First Authorisation/Renewal Of The Authorisation



28 June 2002



10. Date Of Revision Of The Text



April 2003




Monday, July 2, 2012

Nadolol



Pronunciation: NAY-doe-lol
Generic Name: Nadolol
Brand Name: Corgard

Do not suddenly stop taking Nadolol. Sharp chest pain, irregular heartbeat, and sometimes heart attack may occur if you suddenly stop Nadolol. The risk may be greater if you have certain types of heart disease. Your doctor should slowly lower your dose over several weeks if you need to stop taking it. This should be done even if you only take Nadolol for high blood pressure. Heart disease is common and you may not know you have it. Limit physical activity while you are lowering your dose. If new or worsened chest pain or other heart problems occur, contact your doctor right away. You may need to start taking Nadolol again.





Nadolol is used for:

Long-term management of angina (chest pain). It is also used alone or with other medicines to treat high blood pressure. It may also be used for other conditions as determined by your doctor.


Nadolol is a beta-blocker. It works by slowing down the heart and decreasing the amount of blood it pumps out. This helps to decrease blood pressure, helps the heart pump more efficiently, and reduces the workload on the heart.


Do NOT use Nadolol if:


  • you are allergic to any ingredient in Nadolol

  • you have asthma, uncontrolled heart failure, shock caused by serious heart problems, a very slow heartbeat, or certain types of irregular heartbeat (eg, heart block)

  • you are taking mibefradil

Contact your doctor or health care provider right away if any of these apply to you.



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Before using Nadolol:


Some medical conditions may interact with Nadolol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD], bronchitis), diabetes, heart problems (eg, congestive heart failure, slow or irregular heartbeat), overactive thyroid, kidney problems, blood vessel problems, or a tumor on your adrenal gland (pheochromocytoma)

  • if you are scheduled to have surgery or receive anesthesia

Some MEDICINES MAY INTERACT with Nadolol. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Mibefradil because the risk of serious heart side effects may be increased

  • Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, high blood pressure, heart problems, irregular heartbeat, diabetes, depression, mental or mood problems, immune system suppression, allergic reactions, asthma or other lung or breathing problems, high cholesterol, seizures, multiple sclerosis [MS]), multivitamin products, and herbal or dietary supplements (eg, herbal teas, garlic, ginseng, ginkgo, St. John's wort) may interact with Nadolol, increasing the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nadolol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Nadolol:


Use Nadolol as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Nadolol by mouth with or without food.

  • Take Nadolol on a regular schedule to get the most benefit from it. Taking Nadolol at the same time each day will help you remember to take it.

  • Continue to take Nadolol even if you feel well. Do not miss any doses.

  • Do not suddenly stop taking Nadolol. You may have an increased risk of side effects. If you need to stop Nadolol, your doctor will gradually lower your dose.

  • If you miss a dose of Nadolol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Nadolol.



Important safety information:


  • Nadolol may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Nadolol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

  • Do not take more than the recommended dose or change your dose without checking with your doctor.

  • Do not suddenly stop taking Nadolol without talking with your doctor. Sharp chest pain, irregular heartbeat, and sometimes a heart attack may occur if you suddenly stop Nadolol. The risk may be greater if you have certain types of heart disease. The dose should be reduced gradually over a period of several weeks if you need to stop taking it. If new or worsened chest pain or other heart problems develop, contact your doctor right away. You may need to start taking Nadolol again.

  • If your doctor has instructed you to check your blood pressure and heart rate regularly, be sure to do so.

  • Tell your doctor or dentist that you take Nadolol before you receive any medical or dental care, emergency care, or surgery.

  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

  • If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk of an even more severe allergic reaction if you come into contact with the substance that caused your allergy. Some medicines used to treat severe allergies may also not work as well while you are using Nadolol.

  • Diabetes patients- Nadolol may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you hungrier. Nadolol may also affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

  • Lab tests, including blood pressure, electrocardiogram (ECG), heart rate, and heart function tests, may be performed while you use Nadolol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

  • Nadolol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nadolol while you are pregnant. Nadolol is found in breast milk. Do not breast-feed while taking Nadolol.

If you stop taking Nadolol suddenly, you may have WITHDRAWAL symptoms. These may include fast heartbeat, low blood pressure, chest pain, and nervousness.



Possible side effects of Nadolol:


All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Dizziness or tiredness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); behavior changes; blurred vision or other vision changes; burning, numbness, or tingling; fainting; fever, chills, or persistent sore throat; hallucinations; severe or persistent dizziness or light-headedness; short-term memory problems; shortness of breath; slow or irregular heartbeat; sudden, unexplained weight gain; swelling of the hands, ankles, or feet; unusual bruising or bleeding.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Nadolol side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficulty breathing; fainting; light-headedness; severe dizziness; shortness of breath; slow heartbeat; sudden, unexplained weight gain; swelling of the hands, ankles, or feet.


Proper storage of Nadolol:

Store Nadolol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep bottle tightly closed. Keep Nadolol out of the reach of children and away from pets.


General information:


  • If you have any questions about Nadolol, please talk with your doctor, pharmacist, or other health care provider.

  • Nadolol is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Nadolol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Nadolol resources


  • Nadolol Side Effects (in more detail)
  • Nadolol Use in Pregnancy & Breastfeeding
  • Drug Images
  • Nadolol Drug Interactions
  • Nadolol Support Group
  • 11 Reviews for Nadolol - Add your own review/rating


  • Nadolol Prescribing Information (FDA)

  • Nadolol Monograph (AHFS DI)

  • Nadolol Professional Patient Advice (Wolters Kluwer)

  • nadolol Concise Consumer Information (Cerner Multum)

  • nadolol Advanced Consumer (Micromedex) - Includes Dosage Information

  • Corgard Prescribing Information (FDA)



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  • Mitral Valve Prolapse
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Nabumetone



Pronunciation: nab-UE-me-tone
Generic Name: Nabumetone
Brand Name: Relafen

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take Nabumetone for a long time. Do not use Nabumetone right before or after bypass heart surgery.


Nabumetone may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.





Nabumetone is used for:

Treating rheumatoid arthritis or osteoarthritis. It may also be used for other conditions as determined by your doctor.


Nabumetone is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.


Do NOT use Nabumetone if:


  • you are allergic to any ingredient in Nabumetone

  • you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

  • you have recently had or will be having bypass heart surgery

  • you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.



Before using Nabumetone:


Some medical conditions may interact with Nabumetone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

  • if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

  • if you have high blood pressure, a blood disorder, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

  • if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Nabumetone. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

  • Probenecid because it may increase the risk of Nabumetone's side effects

  • Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Nabumetone

  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Nabumetone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nabumetone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Nabumetone:


Use Nabumetone as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Nabumetone comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Nabumetone refilled.

  • Take Nabumetone by mouth. It may be taken with food if it upsets your stomach. This may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor if you have persistent stomach upset.

  • Take Nabumetone with a full glass of water (8 oz/240 mL) as directed by your doctor.

  • If you miss a dose of Nabumetone and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Nabumetone.



Important safety information:


  • Nabumetone may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Nabumetone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Serious stomach ulcers or bleeding can occur with the use of Nabumetone. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Nabumetone with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • Nabumetone is an NSAID. Before you start taking any new medicine, read the ingredients. If it also has an NSAID (eg, ibuprofen) in it, check with your doctor. If you are not sure, check with your doctor or pharmacist.

  • Do not take aspirin while you are using Nabumetone unless your doctor tells you to.

  • Nabumetone may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Nabumetone. Use a sunscreen or wear protective clothing if you must be outside for any length of time.

  • Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

  • Use Nabumetone with caution in the ELDERLY; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

  • Nabumetone should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: Nabumetone may harm the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nabumetone while you are pregnant. It is not known if Nabumetone is found in breast milk. Do not breast-feed while you are taking Nabumetone.


Possible side effects of Nabumetone:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; diarrhea; dizziness; drowsiness; gas; headache; heartburn; nausea; stomach upset.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Nabumetone side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea or stomach pain; slow or troubled breathing; unusual bleeding or bruising; vomit that looks like coffee grounds.


Proper storage of Nabumetone:

Store Nabumetone at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Nabumetone out of the reach of children and away from pets.


General information:


  • If you have any questions about Nabumetone, please talk with your doctor, pharmacist, or other health care provider.

  • Nabumetone is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Nabumetone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Nabumetone resources


  • Nabumetone Side Effects (in more detail)
  • Nabumetone Use in Pregnancy & Breastfeeding
  • Drug Images
  • Nabumetone Drug Interactions
  • Nabumetone Support Group
  • 30 Reviews for Nabumetone - Add your own review/rating


  • Nabumetone Prescribing Information (FDA)

  • Nabumetone Professional Patient Advice (Wolters Kluwer)

  • Nabumetone Monograph (AHFS DI)

  • nabumetone Advanced Consumer (Micromedex) - Includes Dosage Information

  • Relafen Consumer Overview

  • Relafen Prescribing Information (FDA)



Compare Nabumetone with other medications


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Sunday, July 1, 2012

Nystatin Suspension



Pronunciation: nye-STAT-in
Generic Name: Nystatin
Brand Name: Mycostatin


Nystatin Suspension is used for:

Treatment of fungal infections of the mouth. It may also be used for other conditions as determined by your doctor.


Nystatin Suspension is an antifungal. It works by weakening cell membranes of the sensitive fungus. This allows the cell contents to leak out and results in death of the fungus.


Do NOT use Nystatin Suspension if:


  • you are allergic to any ingredient in Nystatin Suspension

Contact your doctor or health care provider right away if any of these apply to you.



Before using Nystatin Suspension:


Some medical conditions may interact with Nystatin Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Nystatin Suspension. However, no specific interactions with Nystatin Suspension are known at this time.


Ask your health care provider if Nystatin Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Nystatin Suspension:


Use Nystatin Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Shake well before each use.

  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • If the mouth is affected, place half the dose in each side of the mouth. Swish the medicine around the entire mouth. Retain the dose in your mouth as long as possible before swallowing, unless directed otherwise by your doctor.

  • Nystatin Suspension works best if it is taken at the same time every day.

  • To clear up your infection completely, take Nystatin Suspension for the full course of treatment. Keep taking it even if you feel better in a few days.

  • If you miss a dose of Nystatin Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Nystatin Suspension.



Important safety information:


  • Practice good oral hygiene, including proper care of dentures, while you are taking Nystatin Suspension.

  • Be sure to use Nystatin Suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

  • Diabetes patients - Nystatin Suspension may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nystatin Suspension while you are pregnant. It is not known if Nystatin Suspension is found in breast milk. If you are or will be breast-feeding while you use Nystatin Suspension, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Nystatin Suspension:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Diarrhea; nausea; stomach irritation; upset stomach; vomiting.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.



If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; high blood pressure; nausea; serious irregular heartbeat; vomiting; wheezing.


Proper storage of Nystatin Suspension:

Store Nystatin Suspension at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Nystatin Suspension out of the reach of children and away from pets.


General information:


  • If you have any questions about Nystatin Suspension, please talk with your doctor, pharmacist, or other health care provider.

  • Nystatin Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Nystatin Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Nystatin resources


  • Nystatin Use in Pregnancy & Breastfeeding
  • Drug Images
  • Nystatin Drug Interactions
  • Nystatin Support Group
  • 3 Reviews for Nystatin - Add your own review/rating


Compare Nystatin with other medications


  • Gastrointestinal Candidiasis
  • Oral Thrush

ADHD (Attention Deficit Hyperactivity Disorder) Medications


Definition of ADHD: An inability to control behaviour due to difficulty in processing neural stimuli. More...

Drugs associated with ADHD

The following drugs and medications are in some way related to, or used in the treatment of ADHD. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

See sub-topics

Topics under ADHD

  • Oppositional Defiant Disorder (1 drug)

Learn more about ADHD (Attention Deficit Hyperactivity Disorder)





Drug List: