Prascion RA

Generic Name: sulfacetamide sodium and sulfur topical (SUL fa SEET a mide SOE dee um and SUL fur TOP i kal)

Brand Names: Avar Cleanser, Avar Gel, Avar LS Cleanser, Avar-E, Avar-E Emollient, Avar-E Green, Avar-e LS, BP 10-Wash, Clarifoam EF, Clenia Emollient Cream, Clenia Foaming Wash, Plexion , Plexion Cleanser, Plexion Cleansing Cloths, Plexion SCT, Prascion, Prascion Cleanser, Prascion FC Cloths, Prascion RA, Rosac, Rosac Wash, Rosaderm Cleanser, Rosanil Cleanser, Rosula, SE 10-5 SS, Sulfacet-R, Sulfatol C, Sulfatol SS, SulZee Wash, Sumaxin, Sumaxin TS, Sumaxin Wash, Suphera, Topisulf, Zencia Wash, Zetacet

What is Prascion RA (sulfacetamide sodium and sulfur topical)?

Sulfacetamide sodium and sulfur are antibiotic that fight bacteria.

The combination of sulfacetamide sodium and sulfur topical (for the skin) is used to treat acne, rosacea, and seborrheic dermatitis (a red, flaking skin rash).

Sulfacetamide sodium and sulfur topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Prascion RA (sulfacetamide sodium and sulfur topical)?

You should not use this medication if you are allergy to sulfa drugs or if you have kidney disease. Avoid getting this medication in your eyes, nose, or mouth. If this does happen, rinse with water.

Do not cover the treated skin area unless your doctor has told you to.

Avoid using other medications on the areas you treat with sulfacetamide sodium and sulfur topical unless you doctor tells you to.

What should I discuss with my healthcare provider before using Prascion RA (sulfacetamide sodium and sulfur topical)?

You should not use this medication if you are allergy to sulfa drugs or if you have kidney disease.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions.

FDA pregnancy category C. It is not known whether sulfacetamide sodium and sulfur topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether sulfacetamide sodium and sulfur topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Prascion RA (sulfacetamide sodium and sulfur topical)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Wash your hands before and after applying this medication.

Do not cover the treated skin area unless your doctor has told you to.

Use this medication regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Prascion RA (sulfacetamide sodium and sulfur topical)?

Avoid getting this medication in your eyes, nose, or mouth. If this does happen, rinse with water. Do not use sulfacetamide sodium and sulfur topical on sunburned, windburned, dry, chapped, irritated, or broken skin.

Avoid using other medications on the areas you treat with sulfacetamide sodium and sulfur topical unless you doctor tells you to.

Prascion RA (sulfacetamide sodium and sulfur topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  new or worsening skin rash;

  
  


• 
  

  joint pain;

  
  


• 
  

  fever; or

  
  


• 
  

  mouth sores.

  
  

Less serious side effects may include redness, warmth, swelling, itching, stinging, burning, or irritation of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Prascion RA (sulfacetamide sodium and sulfur topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied sulfacetamide sodium and sulfur. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Prascion RA resources

• Prascion RA Use in Pregnancy & Breastfeeding
• Prascion RA Drug Interactions
• Prascion RA Support Group
• 0 Reviews for Prascion RA - Add your own review/rating

• Avar LS Cleanser MedFacts Consumer Leaflet (Wolters Kluwer)


• Clarifoam EF Foam MedFacts Consumer Leaflet (Wolters Kluwer)


• Clarifoam EF Prescribing Information (FDA)


• Plexion Prescribing Information (FDA)


• Plexion Cleansing Cloths MedFacts Consumer Leaflet (Wolters Kluwer)


• Plexion SCT Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Plexion TS Emulsion MedFacts Consumer Leaflet (Wolters Kluwer)


• Prascion Cleanser Prescribing Information (FDA)


• Rosac Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Rosaderm Cleanser Prescribing Information (FDA)


• Rosanil Cleanser Prescribing Information (FDA)


• Rosula Foam MedFacts Consumer Leaflet (Wolters Kluwer)


• Rosula Prescribing Information (FDA)


• Rosula Cleanser Emulsion MedFacts Consumer Leaflet (Wolters Kluwer)


• Sumadan MedFacts Consumer Leaflet (Wolters Kluwer)


• Sumadan Wash Prescribing Information (FDA)


• Sumaxin Wash MedFacts Consumer Leaflet (Wolters Kluwer)


• Sumaxin Wash Prescribing Information (FDA)


• Zencia Wash Prescribing Information (FDA)

Compare Prascion RA with other medications

• Acne
• Rosacea
• Seborrheic Dermatitis

Where can I get more information?

• Your pharmacist can provide more information about sulfacetamide sodium and sulfur topical.

Prialt

Generic Name: ziconotide (zye KON oh tide)

Brand Names: Prialt

What is ziconotide?

Ziconotide is a non-narcotic pain reliever that works by blocking pain signals from the nerves to the brain.

Ziconotide is used to treat severe chronic pain in people who cannot use or do not respond to standard pain-relieving medications.

Ziconotide may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ziconotide?

Severe psychiatric symptoms and neurological impairment may occur during treatment with ziconotide. You should not receive ziconotide if you have a history of psychiatric illness or psychotic event.

You should not use this medication if you are allergic to ziconotide, or if you have an uncontrolled bleeding or blood clotting disorder.

Ziconotide must be given only as an intrathecal injection through an infusion pump and should not be injected directly into a vein or other part of the body. Your doctor, nurse, or other healthcare provider will give you this injection.

Your doctor may occasionally change your dose or infusion pump flow rate to make sure you get the best results from this medication.

Tell your doctor if the medicine seems to stop working as well in relieving your pain. Tell your doctor if you regularly use other medicines that make you sleepy. Ziconotide can add to sleepiness caused by these other medications.

Call your doctor at once if you have a serious side effect, especially fever, neck stiffness, seizure (convulsions), extreme drowsiness or tired feeling, confusion, disorientation, hallucinations, thoughts of hurting yourself, or decreased consciousness.

What should I discuss with my healthcare provider before using ziconotide?

Severe psychiatric symptoms and neurological impairment may occur during treatment with ziconotide. You should not receive ziconotide if you have a history of psychiatric illness or psychotic event.

You should not use this medication if you are allergic to ziconotide, or if you have an uncontrolled bleeding or blood clotting disorder.

FDA pregnancy category C. It is not known whether ziconotide is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ziconotide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ziconotide?

Ziconotide is given as an injection into the space around your spinal cord (intrathecal injection) using a computerized, portable infusion pump to control the rate of medication you receive. You may need to use this medication for a period of many years.

Ziconotide must be given only as an intrathecal injection through an infusion pump and should not be injected directly into a vein or other part of the body. Your doctor, nurse, or other healthcare provider will give you this injection.

Your doctor may occasionally change your dose or infusion pump flow rate to make sure you get the best results from this medication.

Tell your doctor if the medicine seems to stop working as well in relieving your pain.

To be sure ziconotide is helping your condition and not causing harmful effects, your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

If you also use a narcotic pain medication, do not stop using it suddenly or you may have unpleasant withdrawal symptoms. Talk with your doctor about using less and less of the narcotic medication before stopping completely.

What happens if I miss a dose?

Since ziconotide dosing and infusion pump programming is administered by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine or if your infusion pump is not working properly.

Overdose symptoms may include extreme drowsiness, vision problems, confusion, speech problems, stiffness in your neck or back, nausea and vomiting, or loss of consciousness.

What should I avoid while using ziconotide?

Avoid drinking alcohol while you are using ziconotide. Ziconotide can cause side effects that may impair your thinking or reactions. Avoid driving or doing anything that requires you to be awake and alert.

Ziconotide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  problems with memory, speech, walking, or thinking;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  double vision or other vision problems;

  
  


• 
  

  new or worsening muscle pain, cramps, soreness, or weakness, and/or dark urine;

  
  


• 
  

  unusual bleeding or signs of infection around the microinfusion entry or catheter exit sites;

  
  


• 
  

  fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, nausea, vomiting, and/or seizure (convulsions);

  
  


• 
  

  extreme drowsiness or tired feeling, depressed mood;

  
  


• 
  

  feeling paranoid, hostile, disoriented, or confused;

  
  


• 
  

  strange sensations in your mouth;

  
  


• 
  

  hallucinations, unusual thoughts or behavior, thoughts of hurting yourself; or

  
  


• 
  

  feeling less alert, decreased consciousness (stupor or lack of response).

  
  

Less serious side effects may include:

• 
  

  headache, joint pain;

  
  


• 
  

  mild drowsiness or weakness;

  
  


• 
  

  dizziness, spinning sensation;

  
  


• 
  

  sleep problems, unusual dreams;

  
  


• 
  

  stomach pain, diarrhea, constipation, loss of appetite;

  
  


• 
  

  urinating less than usual; or

  
  


• 
  

  loss of balance or coordination.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ziconotide?

Before receiving ziconotide, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Ziconotide can add to sleepiness caused by these other medications.

Also tell your doctor if you are taking a diuretic (water pill).

This list is not complete and there may be other drugs that can interact with ziconotide. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Prialt resources

• Prialt Side Effects (in more detail)
• Prialt Use in Pregnancy & Breastfeeding
• Prialt Drug Interactions
• Prialt Support Group
• 0 Reviews for Prialt - Add your own review/rating

• Prialt Prescribing Information (FDA)


• Prialt Monograph (AHFS DI)


• Prialt Advanced Consumer (Micromedex) - Includes Dosage Information


• Prialt Consumer Overview


• Prialt MedFacts Consumer Leaflet (Wolters Kluwer)


• Ziconotide Professional Patient Advice (Wolters Kluwer)

Compare Prialt with other medications

• Pain

Where can I get more information?

• Your pharmacist can provide more information ziconotide.

See also: Prialt side effects (in more detail)

Isoba

Isoba may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Isoba

Isoflurane

Isoflurane is reported as an ingredient of Isoba in the following countries:

• Austria


• Belgium


• Finland


• Germany


• Italy


• Luxembourg


• Netherlands


• Norway


• Sweden

International Drug Name Search

Lacosamide Tablets

Pronunciation: la-KOE-sa-mide
Generic Name: Lacosamide
Brand Name: Vimpat

Lacosamide is used for:

Treating partial-onset seizures in certain patients with epilepsy. It is used in combination with other medicines.

Lacosamide is an anticonvulsant. Exactly how it works is not known, but it may work by slowing abnormal nerve impulses in the brain.

Do NOT use Lacosamide if:

• you are allergic to any ingredient in Lacosamide


• you have severe liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lacosamide:

Some medical conditions may interact with Lacosamide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have diabetes or nerve problems due to diabetes, liver problems, kidney problems, or you are on dialysis


• if you have a history of heart problems (eg, heart failure, heart block, irregular heartbeat), or heart blood vessel problems


• if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions

Some MEDICINES MAY INTERACT with Lacosamide. However, no specific interactions with Lacosamide are known at this time.

Ask your health care provider if Lacosamide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lacosamide:

Use Lacosamide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Lacosamide comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Lacosamide refilled.


• Take Lacosamide by mouth with or without food.


• Taking Lacosamide at the same time each day will help you remember to take it.


• Continue to take Lacosamide even if you feel well. Do not miss any doses.


• Do not suddenly stop taking Lacosamide. You may have an increased risk of side effects (eg, seizures). If you need to stop Lacosamide or add a new medicine, your doctor will gradually lower your dose.


• If you miss a dose of Lacosamide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lacosamide.

Important safety information:

• Lacosamide may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Lacosamide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Lab tests, including electrocardiogram (ECG) or liver or kidney function, may be performed while you use Lacosamide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Lacosamide with caution in the ELDERLY; they may be more sensitive to its effects.


• Lacosamide should be used with extreme caution in CHILDREN younger than 17 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lacosamide while you are pregnant. It is not known if Lacosamide is found in breast milk. Do not breast-feed while taking Lacosamide.

Possible side effects of Lacosamide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; drowsiness; headache; irritability; nausea; tiredness; tremor; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); behavioral changes (eg, aggression; agitation; anger; anxiety; hostility); confusion; dark urine; decreased coordination or loss of balance; double vision or other vision changes; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes (eg, new or worsening depression); new or worsening seizures; severe or persistent drowsiness, tiredness, or weakness; shortness of breath; suicidal thoughts or attempts; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lacosamide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Lacosamide:

Store Lacosamide at 68 to 77 degrees F (20 to 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lacosamide out of the reach of children and away from pets.

General information:

• If you have any questions about Lacosamide, please talk with your doctor, pharmacist, or other health care provider.


• Lacosamide is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lacosamide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Lacosamide resources

• Lacosamide Side Effects (in more detail)
• Lacosamide Dosage
• Lacosamide Use in Pregnancy & Breastfeeding
• Lacosamide Drug Interactions
• Lacosamide Support Group
• 18 Reviews for Lacosamide - Add your own review/rating

Compare Lacosamide with other medications

• Seizures

nystatin vaginal

Generic Name: nystatin vaginal (nye STAT in)

Brand Names:

What is nystatin vaginal?

Nystatin is an antifungal medication. Nystatin prevents fungus from growing.

Nystatin vaginal is used to treat vaginal candida (yeast) infections.

Nystatin vaginal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about nystatin vaginal?

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Avoid wearing tight-fitting, synthetic clothing (such as panty hose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Avoid getting this medication in your eyes, nose or mouth.

What should I discuss with my healthcare provider before using nystatin vaginal?

You should not use nystatin vaginal if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:

• 
  

  fever;

  
  


• 
  

  stomach pain;

  
  


• 
  

  foul-smelling vaginal discharge;

  
  


• 
  

  diabetes; or

  
  


• 
  

  HIV or AIDS.

  
  

Do not use this medication without medical advice if you are pregnant. Do not use nystatin vaginal without medical advice if you are breast-feeding a baby.

How should I use nystatin vaginal?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Wash your hands before and after using this medication.

Insert the tablet into the vagina using the applicator as directed.

Use this medication continuously for the prescribed amount of time, even during your menstrual period.

You can use a sanitary napkin to prevent the medication from staining your clothing but do not use a tampon.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

If the infection does not clear up after you have finished one course of therapy, or if it appears to get worse, see your doctor. You may have another type of infection.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of nystatin vaginal is not expected to be dangerous.

What should I avoid while using nystatin vaginal?

Avoid getting this medication in your eyes, nose, or mouth.

Avoid wearing tight-fitting, synthetic clothing (such as panty hose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Avoid sexual intercourse or use a condom to prevent the infection from spreading to your partner.

Nystatin vaginal side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include mild burning, itching, or irritation, and an increased need to urinate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Nystatin vaginal Dosing Information

Usual Adult Dose for Cutaneous Candidiasis:

Apply nystatin topical cream, ointment or powder in a quantity sufficient to cover the affected area and immediately surrounding skin 2 to 4 times a day.

The powder formulation is useful for the treatment of moist areas or lesions.

Therapy should be continued for 2 to 8 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Vaginal Candidiasis:

Insert one nystatin vaginal tablet (100,000 units) vaginally once a day, preferably at bedtime, for a total of 14 days.

Usual Pediatric Dose for Cutaneous Candidiasis:

Apply nystatin topical cream, ointment or powder in a quantity sufficient to cover the affected area and immediately surrounding skin 2 to 4 times a day.

The powder formulation is useful for the treatment of moist areas or lesions.

Therapy should be continued for 2 to 8 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Vaginal Candidiasis:

>13

What other drugs will affect nystatin vaginal?

Avoid using other vaginal creams or douches at the same time as nystatin unless your doctor approves.

This list is not complete and other drugs may interact with nystatin vaginal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More nystatin vaginal resources

• Nystatin vaginal Use in Pregnancy & Breastfeeding
• Nystatin vaginal Support Group
• 6 Reviews for Nystatin - Add your own review/rating

Compare nystatin vaginal with other medications

• Cutaneous Candidiasis
• Vaginal Yeast Infection

Where can I get more information?

• Your pharmacist has additional information about nystatin vaginal written for health professionals that you may read.

Novo-Methacin Suppositories

Generic Name: indomethacin (Rectal route)

in-doe-METH-a-sin

Rectal route(Suppository)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Indomethacin is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

• Indocin

In Canada

• Indocid


• Novo-Methacin Suppositories


• Ratio-Indomethacin


• Rhodacine

Available Dosage Forms:

• Suppository

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For Novo-Methacin Suppositories

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (e.g., osteoarthritis and rheumatoid arthritis) or gout, such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it.

Indomethacin is also used to treat ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine. This medicine may also be used to treat painful shoulder caused by bursitis or tendinitis.

This medicine is available only with your doctor's prescription.

Before Using Novo-Methacin Suppositories

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of indomethacin in children below 14 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of indomethacin in the elderly. However, elderly patients may be more sensitive to the effects of indomethacin than younger adults, and are more likely to have unwanted effects (e.g., stomach ulcers, confusion, psychosis) and age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving indomethacin.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Pentoxifylline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Certoparin


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Desirudin


• Digoxin


• Dipyridamole


• Enoxaparin


• Escitalopram


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Ginkgo


• Heparin


• Lepirudin


• Methotrexate


• Nadroparin


• Nefazodone


• Parnaparin


• Paroxetine


• Pemetrexed


• Potassium


• Protein C


• Reviparin


• Rivaroxaban


• Sertraline


• Sibutramine


• Tacrolimus


• Ticlopidine


• Tinzaparin


• Tirofiban


• Vilazodone


• Zimeldine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acetohexamide


• Alacepril


• Alprenolol


• Amiloride


• Arotinolol


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desvenlafaxine


• Dilevalol


• Dipyridamole


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gentamicin


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Lithium


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Warfarin


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Bleeding problems or


• Blood clots or


• Depression or other mental changes or


• Edema (fluid retention or body swelling) or


• Heart attack, history of or


• Heart disease (e.g., congestive heart failure) or


• Hepatitis or jaundice, history of or


• Hypertension (high blood pressure) or


• Kidney disease or


• Parkinsonism or


• Seizures or epilepsy, history of or


• Stomach ulcers or bleeding, history of or


• Stroke, history of—Use with caution. May make these conditions worse.

• Aspirin-sensitive asthma, history of or


• Aspirin sensitivity, history of or


• Proctitis (inflammation of the rectum), history of or


• Rectal bleeding, recent—Should not be used in patients with these conditions.

• Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—Should not be used to relieve pain right before or after the surgery.

• Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

Proper Use of indomethacin

This section provides information on the proper use of a number of products that contain indomethacin. It may not be specific to Novo-Methacin Suppositories. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Taking too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

Do not take rectal suppositories by mouth.

To use the suppository:

• If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper.


• Remove the foil wrapper and moisten the suppository with cold water.


• Lie down on your side and use your finger to push the suppository well up into the rectum


• Remain lying down for about 15 minutes to keep the suppository from coming out before it melts.


• Make sure to wash your hands with soap and water before and after inserting this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For rectal dosage form (suppositories):
  
  • For ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, bursitis, tendinitis, or gout:
    
    • Adults and teenagers older than 14 years of age—One 50-milligram (mg) suppository, inserted into the rectum up to four times a day.
    
    
    • Teenagers and children 14 years of age or younger—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Novo-Methacin Suppositories

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain other medicines (such as a steroid medicine or a blood thinner).

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while using this medicine: blistering, peeling, loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, white spots in the mouth or on the lips; or unusual tiredness or weakness.

Some possible warning signs of serious side effects that can occur during treatment with this medicine may include black, tarry stools; decreased urination; severe stomach pain; skin rash; swelling of the face, fingers, feet, or lower legs; unusual bleeding or bruising; unusual weight gain; vomiting of blood or material that looks like coffee grounds; or yellow skin or eyes. Also, signs of serious heart problems could occur, such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of the skin, weakness, or slurring of speech. Stop using this medicine and check with your doctor right away if you notice any of these warning signs.

This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs (NSAIDs). Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once.

Using this medicine in the last few months of a pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if used at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. .

Novo-Methacin Suppositories Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Acid or sour stomach


• belching


• diarrhea


• heartburn


• indigestion


• nausea


• stomach discomfort, upset, or pain


• vomiting

Rare

• Abdominal or stomach cramping, burning, or tenderness


• back or leg pains


• bleeding gums


• blistering, peeling, or loosening of the skin


• bloody or black, tarry stools


• blue lips and fingernails


• blurred vision


• breast enlargement and tenderness


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• burning upper abdominal pain


• canker sores


• change in consciousness


• change in hearing


• chest pain, discomfort, or burning


• clay colored stools


• cloudy or bloody urine


• confusion


• continuing diarrhea


• cough or hoarseness


• coughing that sometimes produces a pink frothy sputum


• cracks in the skin


• dark urine


• decreased appetite


• decreased vision or any change in vision


• depression


• difficult or labored breathing


• difficulty with swallowing


• dilated neck veins


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position


• double vision


• dry mouth


• extreme fatigue


• false sense of well-being


• feeling of unreality


• feeling of warmth


• fever with or without chills


• flushed, dry skin


• fruit-like breath odor


• general body swelling


• greatly decreased frequency of urination or amount of urine


• hair loss


• headache


• heavier menstrual periods


• hives or welts


• increased hunger


• increased sweating


• increased thirst


• increased urination


• irregular breathing


• irritation and swelling of the eye


• itching skin


• jerky movements of the head, face, mouth, and neck


• joint pain


• large, flat, blue or purplish patches in the skin


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• loss of balance control


• loss of bladder control


• loss of consciousness


• loss of hearing


• loss of heat from the body


• lower back or side pain


• mask-like face


• mental confusion


• mood swings


• muscle aches, pains, or weakness


• muscle spasm or jerking of all extremities


• nervousness


• noisy, rattling breathing


• nosebleeds


• numbness or tingling in the hands, feet, or lips


• pain in ankles or knees


• pain or discomfort in upper stomach or throat


• pain with swallowing


• painful or difficult urination


• painful, red lumps under the skin, mostly on the legs


• pale skin


• persistent bleeding or oozing from puncture sites, mouth, or nose


• personality changes


• pinpoint red or purple spots on the skin


• pounding in the ears


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red skin lesions, often with a purple center


• red, irritated eyes


• red, swollen skin


• redness of the face, neck, arms and occasionally, upper chest


• scaly skin


• seeing double


• seeing, hearing, or feeling things that are not there


• seizures


• sense of detachment from self or body


• severe constipation


• severe mental changes


• severe or continuing stomach pain


• shortness of breath


• shuffling walk


• skin rash


• slow, fast, irregular, pounding, or racing heartbeat or pulse


• slowed movements


• slurred speech


• small red or purple spots on the skin


• sore throat


• sores, ulcers, or white spots on the lips or tongue or inside the mouth


• stiffness of the arms and legs


• sudden loss of consciousness


• sugar in the urine


• swelling in the legs and ankles


• swelling of the face, fingers, feet, or lower legs


• swelling of the breasts or breast soreness in both females and males


• swollen or painful glands


• tightness in the chest


• trembling and shaking of the fingers and hands


• troubled breathing at rest


• troubled breathing with exertion


• unexplained weight loss


• unpleasant breath odor


• unsteadiness or awkwardness


• unusual bleeding or bruising


• unusual tiredness or weakness


• vaginal bleeding


• vomiting of blood or material that looks like coffee grounds


• weakness in the arms, hands, legs, or feet


• weight gain


• wheezing


• yellow eyes or skin

Incidence not known

• Frequent urge to defecate


• rectal bleeding, burning, dryness, itching, or pain


• straining while passing stool

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Confusion about identity, place, and time


• severe headache


• unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Mild headache

Less common

• Continuing ringing or buzzing or other unexplained noise in the ears


• difficulty having a bowel movement (stool)


• discouragement


• feeling sad or empty


• general feeling of discomfort or illness


• hearing loss


• irritability


• loss of interest or pleasure


• sleepiness


• trouble with concentrating

Rare

• Anxiety


• bloated full feeling


• changes in patterns and rhythms of speech


• excess air or gas in the stomach or intestines


• feeling of constant movement of self or surroundings


• involuntary muscle movements


• lightheadedness


• passing gas


• sensation of spinning


• sleeplessness


• tiredness


• trouble with speaking


• trouble sleeping


• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Novo-Methacin side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Novo-Methacin Suppositories resources

• Novo-Methacin Suppositories Side Effects (in more detail)
• Novo-Methacin Suppositories Use in Pregnancy & Breastfeeding
• Drug Images
• Novo-Methacin Suppositories Drug Interactions
• Novo-Methacin Suppositories Support Group
• 35 Reviews for Novo-Methacin - Add your own review/rating

Compare Novo-Methacin Suppositories with other medications

• Ankylosing Spondylitis
• Back Pain
• Bartter Syndrome
• Bursitis
• Cluster Headaches
• Frozen Shoulder
• Gitelman Syndrome
• Gout, Acute
• Langerhans' Cell Histiocytosis
• Osteoarthritis
• Pain
• Patent Ductus Arteriosus
• Rheumatoid Arthritis
• Sciatica
• Tendonitis

Norel SR Sustained-Release Tablets

Pronunciation: ah-seet-ah-MIN-oh-fen/klor-fen-EER-a-meen/fen-ill-EF-rin/fen-ill-tole-OX-a-meen
Generic Name: Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine
Brand Name: Norel SR

Norel SR Sustained-Release Tablets are used for:

Relieving symptoms of colds, hay fever, and allergies such as headache, sinus pain, nasal and sinus congestion, sneezing, watery eyes, runny nose, fever, and itching of the nose or throat. It may also be used for other conditions as determined by your doctor.

Norel SR Sustained-Release Tablets are an antihistamine, decongestant, and pain reliever combination. It works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. It also relieves nasal congestion and pain associated with sinus pressure, and dries the nose and chest.

Do NOT use Norel SR Sustained-Release Tablets if:

• you are allergic to any ingredient in Norel SR Sustained-Release Tablets


• you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Norel SR Sustained-Release Tablets:

Some medical conditions may interact with Norel SR Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of breathing problems (eg, emphysema, asthma), heart disease, diabetes, difficulty urinating, an enlarged prostate, glaucoma, high blood pressure, an overactive thyroid, liver or kidney problems, adrenal gland problems (eg, pheochromocytoma), sleep apnea, trouble sleeping, stomach problems, urinary blockage, increased eye pressure, or viral hepatitis


• if you regularly drink large amounts of alcohol

Some MEDICINES MAY INTERACT with Norel SR Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), droxidopa, isoniazid, furazolidone, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects may be increased


• Anticoagulants (eg, warfarin), bromocriptine, furazolidone, MAO inhibitors (eg, phenelzine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because their actions and side effects may be increased by Norel SR Sustained-Release Tablets


• Certain high blood pressure medicines such as beta-blockers (eg, atenolol) and guanethidine because their effectiveness may be decreased by Norel SR Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Norel SR Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Norel SR Sustained-Release Tablets:

Use Norel SR Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Norel SR Sustained-Release Tablets may be taken with food if it upsets your stomach.


• Swallow Norel SR Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing. Some brands of Norel SR Sustained-Release Tablets may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.


• If you miss a dose of Norel SR Sustained-Release Tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Norel SR Sustained-Release Tablets.

Important safety information:

• Norel SR Sustained-Release Tablets may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Norel SR Sustained-Release Tablets. Using Norel SR Sustained-Release Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Norel SR Sustained-Release Tablets will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• Do not exceed the recommended dose of Norel SR Sustained-Release Tablets. Doing so will not improve your condition faster and may increase your risk for side effects.


• If your symptoms do not improve within a few days or if they become worse, check with your doctor.


• Norel SR Sustained-Release Tablets contains acetaminophen and phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen or phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.


• Do not take diet or appetite control medicines while you are taking Norel SR Sustained-Release Tablets without checking with your doctor.


• If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Norel SR Sustained-Release Tablets or other pain relievers/fever reducers. Acetaminophen may cause liver damage. Alcohol use combined with Norel SR Sustained-Release Tablets may increase your risk for liver damage.


• If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take Norel SR Sustained-Release Tablets.


• Caution is advised when using Norel SR Sustained-Release Tablets in the ELDERLY because they may be more sensitive to its effects.


• Use Norel SR Sustained-Release Tablets with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is unknown if Norel SR Sustained-Release Tablets can cause harm to the fetus. If you become pregnant while taking Norel SR Sustained-Release Tablets, discuss with your doctor the benefits and risks of using Norel SR Sustained-Release Tablets during pregnancy. Some of the ingredients in Norel SR Sustained-Release Tablets are excreted in breast milk. If you are or will be breast-feeding while you are using Norel SR Sustained-Release Tablets, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Norel SR Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, nose, or throat; headache; nausea; nervousness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine or pale stools; difficulty urinating; hallucinations; high blood pressure; rapid pulse; severe nervousness; stomach pain; tremors; unusual fatigue; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Norel SR side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fast or irregular heartbeat; fever; hallucinations; nausea; seizures; sweating; tremors; trouble breathing; unusual drowsiness or dizziness; vomiting.

Proper storage of Norel SR Sustained-Release Tablets:

Store Norel SR Sustained-Release Tablets at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Norel SR Sustained-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Norel SR Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Norel SR Sustained-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Norel SR Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Norel SR resources

• Norel SR Side Effects (in more detail)
• Norel SR Use in Pregnancy & Breastfeeding
• Norel SR Drug Interactions
• Norel SR Support Group
• 6 Reviews for Norel SR - Add your own review/rating

Compare Norel SR with other medications

• Nasal Congestion

Nulojix

Generic Name: belatacept (Intravenous route)

bel-AT-a-sept

Intravenous route(Powder for Solution)

Increased risk for developing posttransplant lymphoproliferative disorder (PTLD), predominantly involving the CNS. Recipients without immunity to Epstein-Barr virus (EBV) are at a particularly increased risk; therefore, use in EBV seropositive patients only. Do not use belatacept in transplant recipients who are EBV seronegative or with unknown EBV serostatus. Only physicians experienced in immunosuppressive therapy and management of kidney transplant patients should prescribe belatacept. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. Increased susceptibility to infection and the possible development of malignancies may result from immunosuppression. Use in liver transplant patients is not recommended due to an increased risk of graft loss and death

Commonly used brand name(s)

In the U.S.

• Nulojix

Available Dosage Forms:

• Powder for Solution

Uses For Nulojix

Belatacept injection belongs to a group of medicines known as immunosuppressive agents. It is used together with other medicines to prevent the body from rejecting a transplanted kidney.

When a patient receives a kidney transplant, the body's white blood cells will try to get rid of (reject) the transplanted kidney. Belatacept works by suppressing the immune system and prevents the white blood cells from trying to get rid of the transplanted organ.

This medicine is to be given only by or under the direct supervision of a doctor.

Before Using Nulojix

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of belatacept injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of belatacept injection in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Cytomegalovirus (CMV) infection—Use with caution. May increase risk for more serious side effects.

• Infection (e.g., bacteria, fungus, virus, or protozoa)—May decrease your body's ability to fight infection.

• Tuberculosis infection—Should be treated before starting therapy with this medicine.

Proper Use of Nulojix

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so the needle will need to stay in place for at least 30 minutes.

This medicine comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions While Using Nulojix

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. Be sure to keep all appointments.

It is important to tell your doctor if you become pregnant. Your doctor may want you to join a pregnancy registry for patients using this medicine.

Do not receive this medicine if your doctor says you are Epstein-Barr virus (EBV) negative. Your doctor will test you for EBV.

Using this medicine may increase your risk of having serious conditions called post-transplant lymphoproliferative disorder (PTLD) or progressive multifocal leukoencephalopathy. The risk of developing PTLD is higher in patients who are EBV negative, have cytomegalovirus (CMV) infection, or have received treatments for transplant rejections. Check with your doctor right away if you have changes in mood or usual behavior, confusion, problems with thinking, loss of memory, decreased strength on one side of the body, or changes in vision, walking, or talking.

This medicine may increase your risk of getting certain types of cancer, especially of the skin. Talk to your doctor if you have concerns about this risk.

Use sunscreen or sunblock lotions with a sun protection factor (SPF) of at least 15 on a regular basis when you are outdoors. Wear protective clothing and hats, and stay out of direct sunlight between the hours of 10 a.m. and 3 p.m. Avoid sunlamps and tanning beds.

This medicine may increase your risk of developing infections. Avoid being near people who are sick or have infections while you are using this medicine. Wash your hands often. Tell your doctor if you have any kind of infection before you start using this medicine. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.

You will need to have a skin test for tuberculosis before you start using this medicine. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis skin test.

This medicine may increase your risk for developing a rare and serious virus infection called polyoma virus-associated nephropathy (PVAN). PVAN is caused by BK virus. The BK virus may affect how your kidneys work and cause a transplanted kidney to fail. Check with your doctor right away if you are having more than one of these symptoms: bloody urine; a decreased frequency or amount of urine; increased thirst; loss of appetite; lower back or side pain; nausea; swelling of the face, fingers, or lower legs; trouble with breathing; unusual tiredness or weakness; vomiting; or weight gain.

While you are being treated with belatacept, and after you stop using it, it is important to talk to your doctor about the immunizations (vaccines) you should receive. Do not get any vaccine without your doctor's approval. Belatacept may lower your body's resistance and there is a chance you might get the infection the vaccine is meant to prevent. In addition, other persons living in your household should not receive certain vaccines since there is a chance they could pass the infection on to you. Talk to your doctor if you have questions about this.

Nulojix Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Abdominal or stomach pain


• agitation


• black, tarry stools


• bladder pain


• bloating or swelling of the face, arms, hands, lower legs, or feet


• bloody or cloudy urine


• blurred vision


• bone pain


• burning while urinating


• chest pain


• chills


• coma


• confusion


• convulsions


• cough or hoarseness


• decreased frequency or amount of urine


• decreased urine output


• depression


• difficult or labored breathing


• difficult, burning, or painful urination


• dizziness


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• drowsiness


• dry mouth


• fainting


• fast or irregular heartbeat


• fever


• frequent urge to urinate


• headache


• hostility


• inability to move the arms and legs


• increased blood pressure


• increased thirst


• irritability


• itching in other skin areas


• lethargy


• loss of appetite


• loss of bladder control


• lower back or side pain


• mood or mental changes


• muscle pain or cramps


• muscle spasms (tetany) or twitching


• nausea or vomiting


• nervousness


• numbness or tingling in the hands, feet, or lips


• pale skin


• pounding in the ears


• rapid weight gain


• scaling


• shortness of breath


• slow or fast heartbeat


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• stupor


• sudden decrease in the amount of urine


• sudden numbness and weakness in the arms and legs


• sweating


• swelling of the face, ankles, or hands


• swollen glands


• tightness in the chest


• trembling


• troubled breathing


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusual weight gain or loss


• weakness or heaviness of the legs


• weight gain


• wheezing

Less common

• Back pain


• coughing or spitting up blood


• drowsiness


• joint pain, stiffness, or swelling


• loss of appetite


• night sweats


• persistent non-healing sore


• pink growth reddish patch or irritated area


• shiny bump


• sudden high fever or low-grade fever for months


• swelling of the feet or lower legs


• weight gain


• white, yellow, or waxy scar-like area

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach cramps


• blemishes on the skin


• body aches or pain


• collection of blood under the skin


• cough producing mucus


• deep, dark purple bruise


• diarrhea


• difficulty having a bowel movement (stool)


• difficulty with moving


• dry mouth


• ear congestion


• flushed, dry skin


• fruit-like breath odor


• hair loss or thinning of the hair


• increased hunger


• increased sweating


• increased urination


• itching, pain, redness, or swelling


• loss of consciousness


• loss of voice


• muscle cramps in the hands, arms, feet, legs, or face


• muscle or bone pain


• muscle pain or stiffness


• numbness and tingling around the mouth, fingertips, or feet


• pain in the joints


• pimples


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• sleeplessness


• sneezing


• swelling or inflammation of the mouth


• tightness in the chest


• tremor


• trouble sleeping


• unable to sleep


• unexplained weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Nulojix side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Nulojix resources

• Nulojix Side Effects (in more detail)
• Nulojix Use in Pregnancy & Breastfeeding
• Nulojix Drug Interactions
• Nulojix Support Group
• 0 Reviews for Nulojix - Add your own review/rating

• Nulojix Prescribing Information (FDA)


• Nulojix MedFacts Consumer Leaflet (Wolters Kluwer)


• Nulojix Consumer Overview


• Belatacept Professional Patient Advice (Wolters Kluwer)

Compare Nulojix with other medications

• Rejection Prophylaxis

NyQuil Multi-Symptom

Pronunciation: a-seet-a-MIN-oh-fen/dex-troe-meth-OR-fan/dox-IL-a-meen/sue-do-eh-FED-rin
Generic Name: Acetaminophen/Dextromethorphan/Doxylamine/Pseudoephedrine
Brand Name: Examples include Nite-Time Cold/Flu and NyQuil Multi-Symptom

NyQuil Multi-Symptom is used for:

Relieving symptoms of pain, sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

NyQuil Multi-Symptom is a decongestant, antihistamine, cough suppressant, and analgesic combination. It works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The analgesic and cough suppressant work in the brain to decrease pain and to reduce dry or unproductive cough.

Do NOT use NyQuil Multi-Symptom if:

• you are allergic to any ingredient in NyQuil Multi-Symptom


• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems


• you are unable to urinate or are having an asthma attack


• you take sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using NyQuil Multi-Symptom:

Some medical conditions may interact with NyQuil Multi-Symptom. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, plan to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a fast, slow, or irregular heartbeat


• if you have a history of adrenal gland problems (eg, adrenal gland tumor); heart problems; high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma; a blockage of your bladder, stomach, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; seizures; an overactive thyroid; or liver problems; or if you consume more than 3 alcohol-containing drinks per day


• if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with NyQuil Multi-Symptom. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of NyQuil Multi-Symptom may be increased


• Anticoagulants (eg, warfarin), digoxin, or droxidopa because risk of bleeding, irregular heartbeat or heart attack may be increased


• Bromocriptine or hydantoins (eg, phenytoin) because side effects may be increased by NyQuil Multi-Symptom


• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because effectiveness may be decreased by NyQuil Multi-Symptom

This may not be a complete list of all interactions that may occur. Ask your health care provider if NyQuil Multi-Symptom may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use NyQuil Multi-Symptom:

Use NyQuil Multi-Symptom as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• NyQuil Multi-Symptom may be taken with or without food.


• If you miss a dose of NyQuil Multi-Symptom, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use NyQuil Multi-Symptom.

Important safety information:

• NyQuil Multi-Symptom may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to NyQuil Multi-Symptom. Using NyQuil Multi-Symptom alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Do not take diet or appetite control medicines while you are taking NyQuil Multi-Symptom without checking with your doctor.


• NyQuil Multi-Symptom contains acetaminophen and pseudoephedrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen or pseudoephedrine. If it does or if you are uncertain, contact your doctor or pharmacist.


• Do NOT exceed the recommended dose or take NyQuil Multi-Symptom for longer than prescribed without checking with your doctor.


• If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.


• NyQuil Multi-Symptom may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to NyQuil Multi-Symptom. Use a sunscreen or protective clothing if you must be outside for a prolonged period.


• NyQuil Multi-Symptom may cause liver damage. If you consume 3 or more alcohol-containing drinks every day, ask your doctor if you should take NyQuil Multi-Symptom or other pain relievers/fever reducers. Alcohol use combined with NyQuil Multi-Symptom may increase your risk for liver damage.


• If you are scheduled for allergy skin testing, do not take NyQuil Multi-Symptom for several days before the test because it may decrease your response to the skin tests.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using NyQuil Multi-Symptom.


• Use NyQuil Multi-Symptom with caution in the ELDERLY because they may be more sensitive to its effects.


• Caution is advised when using NyQuil Multi-Symptom in CHILDREN because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking NyQuil Multi-Symptom, discuss with your doctor the benefits and risks of using NyQuil Multi-Symptom during pregnancy. It is unknown if NyQuil Multi-Symptom is excreted in breast milk. Do not breast-feed while taking NyQuil Multi-Symptom.

Possible side effects of NyQuil Multi-Symptom:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; trouble sleeping; vision changes; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: NyQuil Multi-Symptom side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of NyQuil Multi-Symptom:

Store NyQuil Multi-Symptom at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep NyQuil Multi-Symptom out of the reach of children and away from pets.

General information:

• If you have any questions about NyQuil Multi-Symptom, please talk with your doctor, pharmacist, or other health care provider.


• NyQuil Multi-Symptom is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about NyQuil Multi-Symptom. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More NyQuil Multi-Symptom resources

• NyQuil Multi-Symptom Side Effects (in more detail)
• NyQuil Multi-Symptom Use in Pregnancy & Breastfeeding
• NyQuil Multi-Symptom Drug Interactions
• NyQuil Multi-Symptom Support Group
• 2 Reviews for NyQuil Multi-Symptom - Add your own review/rating

Compare NyQuil Multi-Symptom with other medications

• Cold Symptoms